Stroke Risk Rises With Insulin Resistance: Study
Stroke Risk Rises With Insulin Resistance: Study | Photo credit: iStock images
London: Insulin resistance is associated with stroke, according to a study of more than 100,000 people with type 2 diabetes (T2DM), presented at the recent annual meeting of the European Association for the Study of diabetes (EASD). Insulin resistance occurs when cells in the body do not respond properly to insulin and cannot easily absorb glucose from the blood – a key feature of T2DM and levels vary from patient to patient. The higher the insulin resistance, the higher the risk of stroke, the study conducted by a joint team from the Karolinska Institute, Gothenburg University and the National Diabetes Registry in Sweden found.
The team used the estimated glucose elimination rate (eGDR) as a measure of insulin resistance. EGDR has already been shown to be a good indicator of insulin resistance and is calculated using a formula that takes into account a patient’s waist circumference, HbA1c (mean level blood sugar) and high blood pressure.
Medical records were used to calculate the eGDR of 104,697 T2DM patients in Sweden. They were followed for an average of 5.6 years, during which 4,201 (4%) suffered a stroke. People with the lowest insulin resistance (highest eGDR) were 40% less likely to have a stroke than those with the highest insulin resistance. The study also found that higher insulin resistance was linked to a higher risk of death after stroke. Subjects with the lowest resistance were 28% less likely to die during the follow-up period than those with the most severe insulin resistance. Further analysis showed that high blood pressure was more strongly related to stroke than waist circumference or HbA1c.
“We found that in people with type 2 diabetes, low eGDR, a simple measure of insulin resistance, was associated with an increased risk of stroke and death,” said Alexander Zabala of the Karolinska Institute.
“EGDR could be used to help patients with T2DM better understand and manage their risk of stroke and death,” Zabala added.